Дианов Григорий Леонидович, д. б. н. В данный момент не является сотрудником института Подразделение: 103. Лаб. механизмов стабильности генома Должность: главный научный сотрудник Комната: Дистанционная работа Email: DianovGL@icg.sbras.ru

Публикации

2021	Boron-containing nucleosides as tools for boron-neutron capture therapy Zharkov, D. O., Yudkina, A., Riesebeck, T., Loshchenova, P. S., Mostovich, E. A. & Dianov, G. L. [American Journal of Cancer Research]
	Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line Kim D.V., Kulishova L.M., Torgasheva N.A., Melentyev V.S., Dianov G.L., Medvedev S.P., Zakian S.M., Zharkov D.O. [PloS One]
2020	The role of Sp1 in the detection and elimination of cells with persistent DNA strand breaks. Polina S. Loshchenova, Svetlana V. Sergeeva, Sally C. Fletcher and Grigory L. Dianov. [NAR Cancer]
	Sp1-independent downregulation of NHEJ in response to BER deficiency. Loshchenova PS, Sergeeva SV, Limonov DV, Guo Z, Dianov GL. [DNA REPAIR]
2019	E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition. Burdova K, Yang H, Faedda R, Hume S, Chauhan J, Ebner D, Kessler BM, Vendrell I, Drewry DH, Wells CI, Hatch SB, Dianov GL, Buffa FM, D'Angiolella V. [EMBO J]
	Two-way crosstalk between BER and c-NHEJ repair pathway is mediated by Pol-β and Ku70. Xia W, Ci S, Li M, Wang M, Dianov GL, Ma Z, Li L, Hua K, Alagamuthu KK, Qing L, Luo L, Edick AM, Liu L, Hu Z, He L, Pan F, Guo Z. [FASEB J]
2018	Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts. Legrand AJ, Poletto M, Pankova D, Clementi E, Moore J, Castro-Giner F, Ryan AJ, O'Neill E, Markkanen E, Dianov GL. [ONCOTARGET]
	RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. Papaspyropoulos A, Bradley L, Thapa A, Leung CY, Toskas K, Koennig D, Pefani DE, Raso C, Grou C, Hamilton G, Vlahov N, Grawenda A, Haider S, Chauhan J, Buti L, Kanapin A, Lu X, Buffa F, Dianov G, von Kriegsheim A, Matallanas D, Samsonova A, Zernicka-Goetz M, O'Neill E, [NAT COMMUN]
	Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage. Fletcher SC, Grou CP, Legrand AJ, Chen X, Soderstrom K, Poletto M, Dianov GL. [NUCLEIC ACIDS RES]
2017	Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B. [SCI REP-UK]
	Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells. Poletto M, Yang D, Fletcher SC, Vendrell I, Fischer R, Legrand AJ, Dianov GL. [NUCLEIC ACIDS RES]
2016	DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond. Markkanen E, Meyer U, Dianov GL [INT J MOL SCI]
	p53 coordinates base excision repair to prevent genomic instability. Poletto M, Legrand AJ, Fletcher SC, Dianov GL [NUCLEIC ACIDS RES]
2015	Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability Markkanen E, Fischer R, Ledentcova M, Kessler BM, Dianov GL. [NUCLEIC ACIDS RES]
	Inhibiting WEE1 selectively kills histone H3K36me3-deficient cancers by dNTP starvation Pfister SX, Markkanen E, Jiang Y, Sarkar S, Woodcock M, Orlando G, Mavrommati I, Pai CC, Zalmas LP, Drobnitzky N, Dianov GL, Verrill C, Macaulay VM, Ying S, La Thangue NB, D’Angiolella V, Ryan A and Humphrey TC. [CANCER CELL]
	Репарация ДНК в опухолевых стволовых клетках как фактор развития устойчивости глиом к радиотерапии Макушева Ю. С., Дианов Г. Л. [Vavilov journal of genetics and breeding]

Конференции

2020	The interplay between NHEJ and BER in NHEJ deficient cells Polina Loshchenova, Svetlana Sergeeva, Grigory Dianov [BGRS/SB-2020: 12th International Multiconference “Bioinformatics of Genome Regulation and Structure/Systems Biology”]
2019	Interplay between BER and NHEJ in BER deficient cells P.S. Loshchenova, S.V. Sergeeva, D.V. Limonov, Z. Guo, G.L. Dianov. [44th FEBS Congress, "From Molecules to Living Systems"]
2018	Nonthermal impact of terahertz (THz) radiation on living systems S.E. Peltek, I.A. Meshcheryakova, T.N. Goryachkovskaya, E.V. Kiseleva, A.S. Rozanov, E.V. Demidova, K.V. Starostin, A.V. Bryanskaya, S.V. Sergeeva,P.S. Loshenova, D.Y. Oshchepkov, E.A. Demidov, G.L. Dianov, M.A. Logarkova, S.L. Kiselev, M. Timofeeva, N.A. Vinokurov, V.M. Popik, M.A. Scheglov [11th International Multiconference “Bioinformatics of Genome Regulation and Structure\Systems Biology” — BGRS\SB-2018]
	Regulation of base excision repair in response to DNA damage Дианов Григорий Леонидович [International Workshop on Radiation Damage to DNA, Aussois, France]
2017	«The role of cellular responses to DNA repair deficiency in genome stability» Дианов Г.Л. [OpenBio 2017]
	ATM activates a “point of no return” mechanism in response to persistent DNA damage to inforce elimination of genetically unstable cells Дианов Григорий Леонидович [International Ataxia-Telangiectasia Workshops]
2016	"Regulation of DNA polymerase β in response to DNA damage” Dianov G.L. [International symposium in DNA Polymerases: from molecular function to human diseases]
	Base excision repair mechanisms. Introduction. Grigory Dianov [Десятая Международная конференция по биоинформатике регуляции и структуры геномов и системной биологии (Bioinformatics of Genome Regulation and Structure\Systems Biology), BGRS\SB-2016]
	Regulation of base excision repair: new targets for cancer therapy Дианов Григорий Леонидович [International meeting on DNA repair targeting in cancer therapy]
	“Regulation of base excision repair: new targets for cancer therapy” Dianov G.L. [International symposium “DNA repair targeting as cancer therapy”]
2015	DNA base excision repair Дианов Григорий Леонидович [Tomas Lindahl Conference on DNA repair]
	DNA damage recognition, signaling and repair in response to ionizing radiation Дианов Григорий Леонидович [15th International Congress of Radiation Research]

Гранты

2019	Координация репарации ДНК в ответ на долгоживущие разрывы ДНК. Дианов Г.Л., Лощенова П.С., Сергеева С.В.

Научное руководство

2017	Исследование выживаемости фибробластов при дефиците белков, связанных с нарушением функционирования системы эксцизионной репарации ДНК. Макушева Юлия Сергеевна [Михайлов Петр Мизайлович]
	Исследование роли ингибитора PARP в регуляции эксцизионой репарации оснований ДНК в нормальных фибробластах человека. [Лимонов Дмитрий Викторович]
	Молекулярные механизмы противоопухолевой активности лапачона на модели клеточных линий глиом человека [Макушева Юлия Сергеевна]
2016	Исследование роли белка XRCC1 в индукции опухолевой трансформации фибробластов человека. [Ким Дарья Вячеславовна]

Учебные курсы

2020	Основы клинической радиобиологии