Tatyana Frolova Department: Laboratory of Gene Engineering Head: Laboratory of plant protection by RNA interference Room: 5413, 1211, 5406, 1217 Email: frolova@bionet.nsc.ru Work phone: +7 (383) 363-49-63*5406

Publications

2022	A protocol for recruiting and analyzing the disease-oriented Russian disc degeneration study (RuDDS) biobank for functional omics studies of lumbar disc degeneration Olga N. Leonova, Elizaveta E. Elgaeva, Tatiana S. Golubeva, Alexey V. Peleganchuk, Aleksandr V. Krutko, Yurii S. Aulchenko, Yakov A. Tsepilov [PloS One]
	Anti-Inflammatory Activity of Soluble Epoxide Hydrolase Inhibitors Based on Selenoureas Bearing an Adamantane Moiety Vladimir Burmistrov, Christophe Morisseau, Denis Babkov, Tatiana Golubeva, Dmitry Pitushkin, Elena Sokolova, Vladimir Vasipov, Yaroslav Kuznetsov, Sergey Bazhenov, Uliana Novoyatlova, Nikolay Bondarev, Ilya Manukhov, Victoria Osipova, Nadezhda Berberova, Alexander Spasov, Gennady Butov, Bruce Hammock [INT J MOL SCI]
	Investigation of cytotoxic and antioxidative activity of 1,2,3‑triazolyl‑modifed furocoumarins and 2,3‑dihydrofurocoumarins Artemii A. Ivanov, Egor A. Ukladov, Stepan A. Kremis, Sodbo Z. Sharapov, Sergey I. Baiborodin, Alla V. Lipeeva, Elvira E. Shults, Tatiana S. Golubeva [PROTOPLASMA]
	Method for the Isolation of “RNA-seq-Quality” RNA from Human Intervertebral Discs after Mortar And Pestle Homogenization Artemii A. Ivanov, Olga N. Leonova, Daniil S. Wiebe, Alexsandr V. Krutko, Mariya M. Gridina, Veniamin S. Fishman, Yurii S. Aulchenko, Yakov A. Tsepilov, Tatiana S. Golubeva [Cells]
	Molecular and Genetic Aspects of Potato Response to Late Blight Infection T. S. Golubeva, V. A. Cherenko, O. I. Sinitsyna, A. V. Kochetov [RUSS J GENET+]
	Stabilization of Octahedral Metal Halide Clusters by Host–Guest Complexation with γ-Cyclodextrin: Toward Nontoxic Luminescent Compounds Anton A. Ivanov, Mohamed Haouas, Darya V. Evtushok, Tatiana N. Pozmogova, Tatiana S. Golubeva, Yann Molard, Stéphane Cordier, Clément Falaise, Emmanuel Cadot, and Michael A. Shestopalov* [INORG CHEM]
2021	Electrosynthesis of Stable Betulin‐Derived Nitrile Oxides and their Application in Synthesis of Cytostatic Lupane‐Type Triterpenoid‐Isoxazole Conjugates Jevgeņija Lugiņina, Martin Linden, Māris Bazulis, Viktors Kumpiņš, Anatoly Mishnev, Sergey A. Popov, Tatiana S. Golubeva, Siegfried R. Waldvogel, Elvira E. Shults, Māris Turks [EUR J ORG CHEM]
	New model systems for RNA interference in plants to develop eco-friendly and effective antipathogenic tools A. V. Urin, T. S. Golubeva [IOP Conf. Ser.: Earth Env. Sci.]
	Phytophthora infestans: An Overview of Methods and Attempts to Combat Late Blight Artemii A. Ivanov, Egor O. Ukladov, Tatiana S. Golubeva [J Fungi]
	Recent Advances in the Development of Exogenous dsRNA for the Induction of RNA Interference in Cancer Therapy Tatiana S. Golubeva, Viktoria A. Cherenko, Konstantin E. Orishchenko [MOLECULES]
	Silencing of Nicotiana benthamiana phytoendesaturase using dsRNA synthesized in vivo V. A. Cherenko, E. A. Filipenko and T. S. Golubeva [IOP Conf. Ser.: Earth Env. Sci.]
	Synthesis and Cytotoxicity of Sulfanyl, Sulfinyl and Sulfonyl Group Containing Ursane Conjugates with 1,3,4-Oxadiazoles and 1,2,4-Triazoles Semenova M. D., Popov S. A., Golubeva T. S., Baev D. S., Shults E. E., Turks M. [ChemistrySelect]
	ГЕНЕТИЧЕСКИЕ АСПЕКТЫ УСТОЙЧИВОСТИ КАРТОФЕЛЯ К ФИТОФТОРОЗУ Т. С. Фролова, В. А. Черенко, О. И. Синицына, А. В. Кочетов [Vavilov journal of genetics and breeding]
	Рибосомное профилирование как инструмент исследования трансляции у растений: основные итоги, проблемы и перспективы Афонников, Д. А., Синицына, О. И., Голубева, Т. С., Шмаков, Н. А., Кочетов, А. В. [Vavilov journal of genetics and breeding]
2020	0D to 3D coordination assemblies engineered on 2‐(alkylsulfanyl)azine ligands: crystal structures, dual luminescence and cytotoxic activity Maxim Rogovoy, Tatiana Frolova, Denis Samsonenko, Alexey Berezin, Irina Bagryanskaya, Nina Nedolya, Olga Tarasova, Vladimir Fedin, Alexander V. Artem'ev [EurJIC]
	1-Hydroxyanthraquinones Containing Aryl Substituents as Potent and Selective Anticancer Agents Nafisa S. Sirazhetdinova, Victor A. Savelyev, Tatyana S. Frolova, Dmitry S. Baev, Lyubov S. Klimenko, Ivan V. Chernikov, Olga S. Oleshko, Teresa A. Sarojan, Andrey G. Pokrovskii and Elvira E. Shults [MOLECULES]
	Chromones and coumarins from Saposhnikovia divaricata (Turcz.) Schischk. Growing in Buryatia and Mongolia and their cytotoxicity B.M. Urbagarova, E.E. Shults, V.V. Taraskin, L.D. Radnaeva, T.N. Petrova, T.V. Rybalova, T.S. Frolova, A.G. Pokrovskii, Ja. Ganbaatar [J ETHNOPHARMACOL]
	From specific γ‐CD / [Nb6Cl12(H2O)6]2+ recognition to biological activity tuning Pavel A. Abramov, Anton A. Ivanov, Tatiana N. Pozmogova, Anastasiya O. Solovieva, Tatiana S. Frolova, Olga I. Sinitsyna, Olga V. Lundovskaya, Alphiya R. Tsygankova, Mohamed Haouas, David Landy, Enrico Benassi, Lidiya V. Shestopalova, Clément Falaise, Emmanuel Cadot, Michael A. Shestopalov, Maxim N. Sokolov [CHEM-EUR J]
	Lipophilic Metabolites from Five‐Needle Pines, Pinus armandii and Pinus kwangtungensis , Exhibiting Antibacterial Activity Alexander V. Shpatov, Tatyana S. Frolova, Sergey A. Popov, Olga I. Sinitsyna, Olga I. Salnikova, Guangyao Zheng, Linlin Yan, Nadezhda V. Sinelnikova, Lyudmila M. Pshennikova, Alexey V. Kochetov [CHEM BIODIVERS]
	On Functional Properties of Mg-Zn-X Biodegradable Magnesium Alloys Dmitry Merson, Alexander Brilevsky, Pavel Myagkikh, Alexandra Tarkova, Alexei Prokhorikhin, Evgeny Kretov, Tatiana Frolova, Alexei Vinogradov [MATERIALS]
	Synthesis and cytotoxicity of hybrids of 1,3,4- or 1,2,5-oxadiazoles tethered from ursane and lupane core with 1,2,3-triazole Sergey A. Popov, Marya D. Semenova, Dmitry S. Baev, Tatiana S. Frolova, Michael A. Shestopalov, Chengzhang Wang, Zhiwen Qi, Elvira E. Shults, Māris Turks [STEROIDS]
	Water‐soluble rhenium clusters with triazoles: the effect of chemical structure on cellular internalization and the DNA binding of the complexes Dmitry I. Konovalov, Anton A. Ivanov, Tatiana S. Frolova, Ilia V. Eltsov, Yakov M. Gayfulin, Louis Plunkett, Masoomeh Bazzar, Ali M. Adawi, Jean-Sebastien G. Bouillard, Sergey I. Baiborodin, Olga I. Sinitsyna, Natalia V. Kuratieva, Vadim V. Yanshole, Olga A. Efremova, Michael A. Shesto [CHEM-EUR J]
2019	Design, Synthesis and Antibacterial Activity of Coumarin-1,2,3-triazole Hybrids Obtained from Natural Furocoumarin Peucedanin Alla V. Lipeeva, Danila O. Zakharov, Liubov G. Burova, Tatyana S. Frolova, Dmitry S. Baev, Ilia V. Shirokikh, Alexander N. Evstropov, Olga I. Sinitsyna, Tatyana G. Tolsikova, Elvira E. Shults [MOLECULES]
	Disodium salt of glycyrrhizic acid – A novel supramolecular delivery system for anthelmintic drug praziquantel Elizaveta S.Meteleva, Yulia S.Chistyachenko, Lyubov P.Suntsova, Mikhail V.Khvostov, Nikolay E.Polyakov, Olga Yu. Selyutina, Tatyana G.Tolstikova, Tatyana S.Frolova, Viatcheslav A.Mordvinov, Alexander V.Dushkin, Nikolay Z.Lyakhov [J DRUG DELIV SCI TEC]
	Genotoxic activity of 1,2,3-triazolyl modified furocoumarins and 2,3-dihydrofurocoumarins Stepan A. Kremis , Dmitry S. Baev, Alla V. Lipeeva, Elvira E. Shults, Tatiana G. Tolstikova, Olga I. Sinitsyna, Alexey V. Kochetov, Tatiana S. Frolova [J BIOCHEM MOL TOXIC]
	Lupane-type conjugates with aminoacids, 1,3,4- oxadiazole and 1,2,5-oxadiazole-2-oxide derivatives: synthesis, anti-inflammatory activity and in silico evaluation of target affinity Sergey A.Popov, Marya D.Semenova, Dmitry S.Baev, Irina V.Sorokina, Natalya A.Zhukova, Tatyana S.Frolova, Тatyana G.Tolstikova, Elvira E.Shults, MārisTurks [STEROIDS]
	Synthesis of cytotoxic urs-12-ene- and 28-nor-urs-12-ene- type conjugates with amino- and mercapto-1,3,4-oxadiazoles and mercapto-1,2,4-triazoles Sergey A. Popov, Marya D. Semenova, Dmitry S. Baev, Tatiana S. Frolova, Elvira E. Shults, Chengzhang Wang, Māris Turks [STEROIDS]
	Synthesis, hypolipidemic and antifungal activity of tetrahydroberberrubine sulfonates I. V. Nechepurenko, E. D. Shirokova, M. V. Khvostov, T. S. Frolova, O. I. Sinitsyna, A. M. Maksimov, R. A. Bredikhin, N. I. Komarova, D. S. Fadeev, O. A. Luzina, T. G. Tolstikova, N. F. Salakhutdinov [RUSS CHEM B+]
	Влияние гамма-излучения на уровень повреждений ДНК в клетках проростков Аllium cepa L Болсуновский А. Я., Дементьев Д. В., Фролова Т. С., Трофимова Е. А., Иняткина Е. М., Васильев С. А., Синицына О. И. [Doklady Akademii Nauk]
	Исследование цитотоксического эффекта магниевых сплавов на клеточные культуры Т.С. Фролова, А.А. Бойков, А.Р. Таркова, К.Е. Орищенко, А.А. Прохорихин, Д.У. Малаев, О.И. Синицина, В.И. Байструков, Е.И. Кретов, М.В. Прямов, Д.Л. Мерсон, А.Ю. Виноградов [Патология кровообращения и кардиохирургия]
	Синтез, гиполипидемическая и противогрибковая активность сульфонатов тетрагидроберберрубина И. В. Нечепуренко, Е. Д. Широкова, М. В. Хвостов, Т. С. Фролова, О. И. Синицина, А. М. Максимов, Р. А. Бредихин, Н. И. Комарова, Д. С. Фадеев, О. А. Лузина, Т. Г. Толстикова, Н. Ф. Салахутдинов [Известия АН. Серия химическая]
2018	Fluorescent labeling of ursolic acid with FITC for investigation of its cytotoxic activity using confocal microscopy T.S. Frolova, A.V. Lipeeva, D.S. Baev, S.I. Baiborodin, K.E. Orishchenko, A.V. Kochetov, O.I. Sinitsyna [BIOORG CHEM]
	New Ionic Conjugates Based on α-Tocopheryl Succinate as Potential Cytotoxic Agents Frolova, T. S., Sharapov, S. Z., Sinitsyna, O. I., Tolstikova, T. G., Grigoriev, I. A., Morozov, S. V., Yushkova, Y. V. [RUSS J BIOORG CHEM+]
	Orientation-controlled, low-temperature plasma growth and applications of h-BN nanosheets Merenkov, I.S., Myshenkov, M.S., Zhukov, Y.M., Sato, Y., Frolova, T.S., Danilov, D.V., Kasatkin, I.A., Medvedev, O.S., Pushkarev, R.V., Sinitsyna, O.I., Terauchi, M., Zvereva, I.A., Kosinova, M.L., Ostrikov K. [NANO RES]
	Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry Qihong Zhang, Nikolay E. Polyakov, Yulia S. Chistyachenko, Mikhail V. Khvostov, Tatjana S. Frolova, Tatjana G. Tolstikova, Alexandr V. Dushkin, Weike Su [DRUG DELIV]
	НОВЫЕ ИОННЫЕ КОНЪЮГАТЫ НА ОСНОВЕ a-ТОКОФЕРИЛСУКЦИНАТА КАК ПОТЕНЦИАЛЬНЫЕ ЦИТОТОКСИЧЕСКИЕ АГЕНТЫ Фролова Т. С., Шарапов С. Ж., Синицына О. И., Толстикова Т. Г., Григорьев И. А., Морозов С. В., Юшкова Ю. В. [Биоорганическая химия]
2017	Apoptosis as the Basic Mechanism of Cytotoxic Action of Ursolic and Pomolic Acids in Glioma Cells Frolova T.S., Lipeeva A.V., Baev D.S., Tsepilov Y. A., Sinitsyna O.I. [Molecular Biology]
	Апоптоз как основной механизм цитотоксического действия урсоловой и помоловой кислот в клетках глиомы Фролова Т.С., Липеева А.В., Баев Д.С., Цепилов Я.С., Синицына О.И. [Molecular Biology]
2016	Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides. Zakharova OD, Frolova TS, Yushkova YV, Chernyak EI, Pokrovsky AG, Pokrovsky MA, Morozov SV, Sinitsina OI, Grigor'ev IA, Nevinsky GA. [EUR J MED CHEM]
	Genotoxicity Assessment of Low-Level Doses of Gamma Radiation with the SOS Chromotest and the Ames Test A. Ya. Bolsunovsky, O. I. Sinitsyna, T. S. Frolova, E. A. Vasyunina, D. V. Dementyev [Doklady Biochemistry and Biophysics]
	Low doses of gamma-radiation induce SOS response and increase mutation frequency in Escherichia coli and Salmonella typhimurium cells Alexander Bolsunovsky, Tatiana Frolova, Dmitry Dementyev, Olga Sinitsyna [ECOTOX ENVIRON SAFE]
	ОЦЕНКА ГЕНОТОКСИЧНОСТИ МАЛЫХ ДОЗ ГАММА-ИЗЛУЧЕНИЯ С ПОМОЩЬЮ SOS-ХРОМОТЕСТА И ТЕСТА ЭЙМСА А. Я. Болсуновский, О. И. Синицына, Т. С. Фролова, Е. А. Васюнина, Д. В. Дементьев [Doklady Akademii Nauk]
2015	CONJUGATES OF TROLOX AND a-TOCOPHERYL SUCCINATE WITH NITROXIDES: SYNTHESSIS, ANTIOXIDANT AND ANTITUMOR ACTIVITY TAT’YANA S. FROLOVA, OL’GA D. ZAKHAROVA, YULIYA F. POLIENKO, YULIYA V. YUSHKOVA, ELENA I.CHERNYAK, SERGEI V.MOROZOV, OL’GA I. SINITSINA, IGOR A. GRIGOR’EV & GEORGY A. NEVINSKY [International Journal of Medicine and Pharmaceutical Sciences]
	Genotoxic and Mutagenic Properties of Synthetic Betulinic Acid and Betulonic Acid T. S. Frolovaa, T. P. Kukina, O. I. Sinitsyna [RUSS J BIOORG CHEM+]
	МУТАГЕННАЯ АКТИВНОCТЬ В ТЕCТЕ ЭЙМCА ЧЕТЫPЕX АМИНОАЗОCОЕДИНЕНИЙ C PАЗЛИЧНОЙ КАНЦЕPОГЕННОCТЬЮ ДЛЯ ПЕЧЕНИ КPЫC Т.C. Фpолова, О.И. Cиницына, В.И. Каледин [BIOPHYSICS]
2014	Isolation of Pomolic Acid from Chamaenerion angustifolium and the Evaluation of Its Potential Genotoxicity in Bacterial Test Systems T. S. Frolovaa, O. I. Sal’nikova, T. A. Dudareva, T. P. Kukina, and O. I. Sinitsyna [RUSS J BIOORG CHEM+]
2013	SYNTHESIS AND STUDY OF MUTAGENIC PROPERTIES OF LUPANE TRITERPENOIDS CONTAINING 1,2,3-TRIAZOLE FRAGMENTS IN THE C-30 POSITION A. N. Antimonova, N. I. Petrenko, M. M. Shakirov, T. V. Rybalova, T. S. Frolova, E. E. Shults, T. P. Kukina, O. I. Sinitsyna, and G. A. Tolstikov [CHEM NAT COMPD+]