Aleksander Smirnov Department: Laboratory of Developmental Genetics Head: Laboratory of the 3D genetics of breaks Pluralist: Laboratory of Genome Stability Room: 1011, 1019, 1023 Email: smirnovskaven@bionet.nsc.ru Work phone: +7(383) 363-49-63*1011

Publications

2024	Assessing cell lines with inducible depletion of cohesin and condensins components through analysis of metaphase chromosome morphology A. M. Yunusova, A. V. Smirnov, I. E. Pristyazhnuk, T. A. Shnaider, E. K. Maltseva, S. D. Afonnikova, O. A. Gusev, N. R. Battulin [Vavilov journal of genetics and breeding]
	Characterizing a Lethal CAG-ACE2 Transgenic Mouse Model for SARS-CoV-2 infection with Using Cas9-Enhanced Nanopore Sequencing Smirnov A, Nurislamov A, Galina Koncevaya G, Serova I, Kabirova E, Chuyko E, Maltceva E, Savoskin M, Zadorozhny D, Svyatchenko VA, Protopopova EV, Taranov OS, Legostaev SS, Loktev VB, Serov O, Battulin N [TRANSGENIC RES]
	TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene. Kabirova E, Ryzhkova A, Lukyanchikova V, Khabarova A, Korablev A, Shnaider T, Nuriddinov M, Belokopytova P, Smirnov A, Khotskin NV, Kontsevaya G, Serova I, Battulin N. [NAT COMMUN]
2023	Function and Evolution of the Loop Extrusion Machinery in Animals Evelyn Kabirova, Artem Nurislamov, Artem Shadskiy, Alexander Smirnov, Andrey Popov, Pavel Salnikov, Nariman Battulin, Veniamin Fishman [INT J MOL SCI]
	Ultrastructural Abnormalities in Induced Pluripotent Stem Cell-Derived Neural Stem Cells and Neurons of Two Cohen Syndrome Patients Shnaider TA, Khabarova AA, Morozova KN, Yunusova AM, Yakovleva SA, Chvileva AS, Wolf ER, Kiseleva EV, Grigor’eva EV, Voinova VY, Lagarkova MA, Pomerantseva EA, Musatova EV, Smirnov AV, Smirnova AV, Stoklitskaya DS, Arefieva TI, Larina DA, Nikitina TV, Pristyazhnyuk IE [Cells]
2022	Evaluation of the α‑casein (CSN1S1) locus as a potential target for a site‑specifc transgene integration Смирнов А. В., Концевая Г. В., Шнайдер Т. А., Юнусова А. М., Феофанова Н. А., Герлинская Л. А., Серова И. А., Серов О. Л., Баттулин Н. Р. [SCI REP-UK]
	Generation of two iPSC lines from healthy donor with a heterozygous mutation in the VPS13B gene S.A.Chechetkina, A.A.Khabarova, A.S.Chvileva, O.M.Kurchenko, A.V.Smirnov, A.M.Yunusova, I.N.Kotov, E.V.Musatova, E.A.Pomerantseva, E.A.Volovikov, M.A.Lagarkova, T.A.Shnaider, I.E.Pristyazhnyuk [STEM CELL RES]
	The human EF1a promoter does not provide expression of the transgene in mice Nariman Battulin, Alexey Korablev, Anastasia Ryzhkova, Alexander Smirnov, Evelyn Kabirova, Anna Khabarova, Timofey Lagunov, Irina Serova, Oleg Serov [TRANSGENIC RES]
2021	A hypomorphic mutation in the mouse csn1s1 gene generated by CRISPR/Cas9 pronuclear microinjection A V Smirnov, T А Shnaider, A N Korablev, A M Yunusova, I A Serova, N R Battulin [Vavilov journal of genetics and breeding]
	Concatenation of transgenic DNA: random or orchestrated? Alexander Smirnov, Nariman Battulin [Genes]
	Evaluation of the OsTIR1 and AtAFB2 AID Systems for Genome Architectural Protein Degradation in Mammalian Cells Anastasia Yunusova*, Alexander Smirnov, Tatiana Shnaider, Varvara Lukyanchikova, Svetlana Afonnikova and Nariman Battulin* [Front Mol Biosci]
	Создание библиотек баркодированных плазмид с помощью метода клонирования по Гибсону А.В. Смирнов, А.М. Юнусова, А.А. Муравьева, Э.C. Валеев, В.C. Фишман, Н.Р. Баттулин [Письма в Вавиловский журнал генетики и селекции]
2020	DNA barcoding reveals that injected transgenes are predominantly processed by homologous recombination in mouse zygote Alexander Smirnov, Veniamin Fishman, Anastasia Yunusova, Alexey Korablev, Irina Serova, Boris V Skryabin, Timofey S Rozhdestvensky, Nariman Battulin [NUCLEIC ACIDS RES]
2018	Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice Smirnov A.V., Kontsevaya G.V., Feofanova N.A., Anisimova M.V., Serova I.A., Gerlinskaya L.A., Battulin N.R., Moshkin M.P., Serov O.L. [TRANSGENIC RES]
2017	Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice Smirnov AV, Kontsevaya GV, Feofanova NA, Anisimova MV, Serova IA, Gerlinskaya LA, Battulin NR, Moshkin MP, Serov OL [TRANSGENIC RES]
2016	Морфофизиологические эффекты инсерционного мутагенеза гена контактин 5 (Cntn5) у трансгенных мышей А. В. Смирнов, Н. А. Феофанова, Г. В. Концевая, М. В. Анисимова, И. И. Ковригин, И. А. Серова, М. П. Мошкин, Л. А. Герлинская, Н. Р. Баттулин [Vavilov journal of genetics and breeding]
	Система CRISPR/Cas9 – универсальный инструмент геномной инженерии Смирнов Александр Васильевич Юнусова Анастасия Маратовна Лукьянчикова Варвара Алексеевна Баттулин Нариман Рашитович [Vavilov journal of genetics and breeding]
	Эффективное получение химерных мышей с использованием новой линии эмбриональных стволовых клеток Концевая Г.В., Феофанова Н.А., Мензоров А.Г., Пристяжнюк И.Е., Смирнов А.В., Баттулин Н.Р., Герлинская Л.А. [Vavilov journal of genetics and breeding]
2013	Expression of the human granulocyte–macrophage colony stimulating factor (hGM-CSF) gene under control of the 50-regulatory sequence of the goat alpha-S1-casein gene with and without a MAR element in transgenic mice I. A. Burkov • I. A. Serova • N. R. Battulin • A. V. Smirnov • I. V. Babkin • L. E. Andreeva • G. A. Dvoryanchikov • O. L. Serov [TRANSGENIC RES]
2012	A 3,387 bp 5'-flanking sequence of the goat alpha-S1-casein gene provides correct tissue-specific expression of human granulocyte colony-stimulating factor (hG-CSF) in the mammary gland of transgenic mice Serova IA, Dvoryanchikov GA, Andreeva LE, Burkov IA, Dias LPB, Battulin NR, Smirnov AV, Serov OL [TRANSGENIC RES]